Biochemistry question

BCQ Test for Batch-26
2)- AT WHICH OF THE FOLLOWING ENZYME –CATALYZED STEPS OF THE
TRICARBOXLYLIC ACID CYCLE, DO(ES) NET INCORPORATION OF WATER INTO AN
INTERMEDIATE OF THE CYCLE OCCUR:
(A)
(B)
(C)
(D)
(E)
Citrate synthase.
Succinyl CoA sythase.
Malate Dehydrogenase.
Aconitase.
α – ketoglutarate D.H.
3)- THE FREELY REVERSIBLE REACTION OF THE TRICARBOXYLIC ACID CYCLE
INCLUDE:
(A)
(B)
(C)
(D)
(E)
The citrate synthase reaction.
The isocitrate dehydeogenase reaction.
The α – ketoglutarate dehydrogenase reaction.
The succinyl CoA synthase reaction.
The pyruvate D.H reaction.
4)- WHICH OF THE FOLLOWING TRICARBOXYLIC ACID CYCLE INTERMEDIATES MAY
BE ADDED OR REMOVED BY OTHER METABOLIC PATHWAY:
(A) Oxalosuccinate.
(B) α – ketoglutarate.
(C) Isocitrate.
(D) Oxloacetate.
(E) Citrate.
5)- THE MITOCHONDRIAL MEMBRANE CONTAINS A TRANSPORTER FOR:
(A)
(B)
(C)
(D)
(E)
NADH .
Acetyl CoA.
GTP.
ATP.
Cyclic AMP.
6)- ADP CAN RECEIVE A PHOSPHATE GROUP FROM:
(A) Fructose -6-phosphate.
(B) Glycerol-3-Phosphate.
(C) Creatine phosphate.
(D) Glusoce-6-Phosphate.
(E) 1-3-bisphosphoglycerate.
7)- THE HIGHEST GROUP TRANSFER POTENTIAL IS PRESENT AMONGST THE
FOLLOWING IN:
(A)
(B)
(C)
(D)
(E)
1.3-Biphospholglycerate.
Creatine phosphate.
Carbamoyl phosphate.
Phosphoenol pyruvate.
Glucose-6-P.
8)- THE COMPOUND HAVING THE LOWEST REDOX POTENTIAL AMONGST THE
FOLLOWING IS:
(A)
(B)
(C)
(D)
(E)
Hydrogen.
NAD.
Cytochrome b.
Cytochrome a.
Cytochrome c.
9)- WHEN REDUCING EQUIVALENTS ENTER THE RESPIRATORY CHAIN THROUGH
NAD, THE P:O RATIO IS:
(A) 1:2 .
(B) 2:1.
(C) 1:3.
(D) 3:1.
(E) 2:2.
10)- A COPPER CONTAIN CYTOCHROME IS
(A)
(B)
(C)
(D)
(E)
Cytochrone c.
Cytochrome P – 450.
Cytochrome b.
Cytochrome oxidase.
Cytocheome c1.
11)- CYTOCHROME P450 IS A MEMBER OF WHICH FAMILY OF OXIDOREDUCTASES?
(A)
(B)
(C)
(D)
(E)
Catalase.
Hydeoperoxidase.
Oxidase.
Oxygenase.
Dehydrogenases.
12)- THE CONVERSION OF GLUCOSE TO GLUCOSE-6-PHOSPHATE TAKE PLACE IN THE
CELL BECAUSE:
(A)
(B)
(C)
(D)
(E)
The reaction has a positive Δ G0`.
The reaction has a negative Δ G0`.
Glucose-6-phosphate is unstable.
There is no enzyme capable of catalyzing this reaction.
G-6-P is a functional compound.
14)- WHICH OF THE FOLLOWING REACTIONS GENERATES ATP ?
(A)
(B)
(C)
(D)
(E)
Glucose-6-phosphate to fructose-6-phosphate.
Glucose to glucose-6-phosphate.
Fructose-6-phosphate to fructose-1,6-disphosphate
Phospoenolpyruvate to pyruvate .
Pyruvate to lactate.
16)- CITRIC ACID CYCLE IS REGULATED BY:
(A) High glucose concentration.
(B) Low glucose Conc:.
(C) High Conc: of Acetyl CoA.
(D) Hormones.
(E) Cirtrate and ATP / AMP ratio.
17)- INORGANIC PHOSPHATE IS INCORPORATED IN THE SUBSTRATE BY:
(A) Glyceraldehde-3-phosphate dehydrogenase.
(B) Phosphoglycerate kinase.
(C) Pyruvate kinase.
(D) Enolase.
(E) Aldolase.
18)- BIPHOSPHOGLYCERATE MUTASE IS PRESENT IN
(A) Liver.
(B) Muscles.
(C) Brain.
(D) Erythrocytes.
(E) Heart.
19)- GLUCOSE-6-PHOSPHATE DEHYDROGENASE IS INDUCED BY:
(A)
(B)
(C)
(D)
(E)
6-Phosphogluconolactone.
Glucose-6-phosphate.
Ribose-5-phosphate.
Insulin.
Glucogon.
20)- THE FIRST PENTOSE FORMED IN HMP SHUNT IS:
(A)
(B)
(C)
(D)
(E)
Ribose-5-phosphate.
Ribulose-5-phosphate.
Xylose-5-phosphate.
Xylulose-5-phosphate.
PRPP.
21)- INCREASED REABOSRPTION OF WATER FROM THE KIDNEY IS THE MAJOR
CONSEQUENCE OF WHICH OF THE FOLLOWING HORMONES:
(A) Cortisol.
(B) Insulin.
(C) Vasopressin.
(D) Glucagon.
(E) Aldosterone
22)- WHICH OF THE FOLLOWING HORMONES CAN CAUSE HYPERGLYCEMIA WITHOUT
KNOWN EFFECTS ON GLYCOGEN OR GLUCONEOGENESIS:
(A) Thyroxine.
(B) Epinephrine.
(C) Glucocorticoids.
(D) Epidermal growth factor.
(E) Glucagon
23)- WHICH OF THE FOLLOWING IS NOTED IN CUSHING’S SYNDROME, A DISEASE OF THE
ADRENAL CORTEX:
(A)
(B)
(C)
(D)
(E)
Decreased production of epinephrine.
Excessive production of epinephrine.
Excessive production of vasopressin.
Excessive production of cortisol.
Decreased production of cortisol.
24)- WHICH OF THE FOLLOWING PROTEINS IS RESPONSIBLE FOR SECRETION OF
PANCREATIC JUICE INTO THE INTESTINE:
(A)
(B)
(C)
(D)
(E)
Cholecystokinin.
Gastrin.
Insulin.
Intrinsic factor.
Secretin
Questions of Sir Arjan Das
1)- GLUCOKINASE
(A) Formed in all tissues.
(B) Km is low hence high affinity for glucose.
(C) Specific for all carbohydrate.
(D) Active in hypoglyemia.
(E) Active during high intake of CHO diet.
)- HER’S DISEASE (GLYCOGEN STORAGE DISEASE TYPE-VI ) OCCURS DUE TO THE
DEFECTIONS OF:
(A) Acid maltase.
(B) Muscle phosphorylase.
(C) Liver phosphosrylase.
(D) Glucose 6-phosphatase.
(E) Branching enzyme.
3)- WHICH MONOSACHRIDES IS ABSORBED EARLIER:
(A) Fructose.
(B) Mannose.
(C) Xylose.
(D) Glucose.
(E) Galatose.
4)- THE ACTIVE SITE FOR ABSORPTION FOR CARBOHYDRATE IS:
(A) Stomach.
(B) Jejunum.
(C) Dudenum.
(D) Ileum.
(E) Large intestine.
5)- RENIN:
(A)
(B)
(C)
(D)
(E)
Proteolytic enzyme present in gastric juice.
Convert aniotensinogen to angiotensin I.
Causes increased blood pressure.
Proteolytic enzyme present in pancreatic juice.
Converts angiotensin II to angiotensin I.
Questions of Sir Hanif Shaikh
1)- SALIVA
(A) Saliva from parotid gland is mucus.
(B) Saliva from sublingual gland is serous.
(C) Increase secretion b/c of vesodilation of parasympathtic stimulation.
(D) Vasodilation is due to secretion of histamine.
(E) pH is almost acidic.
2)- GASTRIC JUICE:
(A)
(B)
(C)
(D)
(E)
Chief cells secrete Hcl.
Parietal cells secrete pepsinogen.
Pepsmogen is activated by enterokinase.
pH is highly acidic due to weak acid like Hcl.
Main organic coustituent is enzymes and intrinsic factor.
3)- REGARDING GASTRIC JUICE
(A)
(B)
(C)
(D)
(E)
Increase secretion due to bradykinin by entrance of fatty food.
Decrease by entrance of CHO diet.
Cephelic phase is stimulated by entrance of food in stomach.
Gastric phase is started when stimulation like smell, sight and taste.
Gastrin increase the secretion.
4)- SECRETION OF GASTRIC JUICE IS DECREASED BY:
(A) Histamine.
(B) Cholcystokin pancreozymin.
(C) Proteins.
(D) Alkalies.
(E) Acids.
5)- PANCREATIC JUICE
(A) It is mucoid in nature.
(B) Organic constituent is mainly HCo3.
(C) pH is alkaline due to excessive amount of enzymes.
(D) Secretion is increased in fasting.
(E) Trypsin is main proteolytic enzyme.
6)- REGULATION OF PANCREATIC SECRETION
(A) Decreases its secretion.
(B) Sympathetic stimulation increases its secretion.
(C) CCKPZ secretion increased in response to CHO.
(D) CCK PZ increased its secretion.
(E) Increased in response to enzyme.
7)- BILE JUICE:
(A) Biliverdin is major bile pigment.
(B) Increase amino acid absorption increases bile secretion.
(C) Glycine is only amino acid that form bile acids / bile salts.
(D) Fatty meal increase the formation of bile salts.
(E) Carbohydrates increase the formation of bile salts .
8)- CARBOHYDRATES DIGESTION ABSORPTION:
(A) α – amylase is activated in acidic medium .
(B) glucose require insulin for uptake in enteryocytes.
(C) fructose is easily transported than glucose.
(D) Galactose are more digestive form of CHO for absorption.
(E) CHO is only absorbed in small intestine.
9)- PROTEIN DIGESTION AND ABSORPTION:
(A) Pepsinogen is necessary for digestion of protein .
(B) Elastase is spectic for elastin.
(C) Collagenase is specific for collegen.
(D) One amino acids can not inhibit absorption of another amino acid.
(E) Chymotrypsinogen is activated by Hcl.
10)- FAT DIGESTION AND ABSORPTION:
(A) More than 30 % fat is digested in mouth by lingual lipase.
(B) Gastric lipase hydrolyse the TAG.
(C) Glycerol is only form of absorption.
(D) Vitamin D help the fat for absorption.
(E) Bile Salts help the absorption of cholesterol.
11)- THYROID HORMONES:
(A) Acts by decreased in-tracellular cyclic AMP.
(B) Mobilize Ca+ ions from bones.
(C) Is transported in blood by globulins.
(D) Deficiency in intrauterrine life leads to myxedema.
(E) Decreases protein systhesis by transcription.
12)- REGARDING HORMONE ACTION:
(A) Steroid hormones involve structure gene transcription.
(B) Insulin in muscles decrease cyclic AMP activity .
(C) Thyroxine acts in the cytoplasmic mitochondrial enzymes.
(D) Catecholamins act through cyclic AMP .
(E) The Receptors of growth hormones are present in E.R.
13)- THYROID HORMONES:
(A) Receptors are locate in cytosol of target cells.
(B) Supress the expression of specific genes.
(C) In low dose uncouple the oxidative phosphrylation.
(D) Increase oxygen utilization by mitochondria.
(E) Are dehydrogenated in liver and kidneys.
14)- GLUCOGON:
(A)
(B)
(C)
(D)
(E)
Promote glycogenesis.
Is composed of two polypeptide chains.
Supress cyclic AMP formation in liver .
Decrease fatty acids in blood.
Is Secreted in response to hypoglycemia.
15)- INSULIN:
(A)
(B)
(C)
(D)
(E)
Having two alpha and two gamma polypetede chains.
Decrease uptake of amino acids by the cells.
Increase ketogenesis in liver.
Increase gluconeogensis.
Increase fatty acids synthesis
16)- HORMONES RECEPTORS OF:
(A)
(B)
(C)
(D)
(E)
Epinephrine are on the cell memberane.
Calcitonin on golgi apparatus.
Thyroxine are in mitochondria.
Glucogon in ER.
Parathroid are in cytoplasm.
17)- REGARDING CRETINISM:
(A) Is due to deficiency of prothyroid hormones
(B) Is disease of adult.
(C) Diarrhoea is constant feature.
(D) The hands and feet are enlarge.
(E) Tongue is enlarge
18)- ANABOLIC HORMONES IS:
(A)
(B)
(C)
(D)
(E)
cortisol.
Thyroxine.
Glucogan.
Testosterone.
Adrenaline.
19)- SEVERE HYPOGLYCEMIA MAY SEEN IN:
(A)
(B)
(C)
(D)
(E)
Acromegaly.
Cushing syndrome.
Glycogen storage disease.
Insulinoma.
Over dose of insulin.
Q.1. Write the enzymes of pancreatic juice.
Q.2. Write Digestion & absorption of carbohydrates.
Q.3. Write characteristics feature and cause of Glycogen storage disease type – I (von Gierke`s
disease)
Q.4. Write the mechanism of action of hormones that act via G-protein cascade with examples
Q.5. Write mechanism of action of Insulin
Q.6. Name the key enzymes of gluconeogenesis and describe role of “malate shuttle”
Q.7. Write Cori’s lactic acid cycle
Q.8. (a) Write the complexes / components of respiratory chain
(b) Role of uncouplesr with examples
Name:
Description:
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