Describe the mechanisms of action, biochemical targets and effects o
Describe the mechanisms of action, biochemical targets
and effects of these 7 lipid-lowering drugs:
NIACIN: Niacin inhibits the lipolysis in the adipose tissue
,which produces the free fatty acids ,finally plasma
triacylglycerol and cholesteroll are lowered .
It increases lipoprotein lipase in the adipose and muscle
cells ,which increases triglycerides clearance from
circulating VLDL .
Increases the half life of apolipoprotein ,which increases
COLESTIPOL:It binds to the bile acids int he
intestine,which increases the conversion of cholesterol in
to the bile acids .
It increases the clearance of LDL cholesterol from blood .
TORCETRAPIB: It inhibits cholesterylester transfer protein
It increases HDL and apolipoprotein A1 levels,it decreases
LDL and apolipoprotein -B
AVASIMIBE: It inhibits enzyme cholesterol acyltransferase
IMPLITAPIDE: it inhibits (MTP) microsomal triglyceride
transfer protein,reduces the levels of Apolipoprotein -B
and LDL .
PRALUENT:It is an monoclonal antibody that inhibits an
enzyme proprotein convertase subtilisin/kexin type 9
(PCSK9),which increases the reuptake of LDL by the liver
and increases the clearance of LDL .
EZETIMIBE:It inhibits the absorption of cholesterol at the
rush broder of the small intestine ,which decreases the
cholesterol uptake by the liver .