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Pharmacokinetics practice problems part 2

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October 22nd, 2022

Pharmacokinetics Practice Questions
1. Constant Infusion: the infusion rate for Drug X is
150 ug/min; half-life for elimination is 15 hours; ke
= 0.046/hr; Vd = 40L: What is the Css?
A. ?
0.082 ug/ml
B. ?
4.89 ug/ml
C. ?
4,89 mg/ml
D. ?
9.8 ug/ml
E. ?
0.0489
2. Constant Infusion: the infusion rate for Drug X is
150 ug/min; half-life for elimination is 15 hours; ke
= 0.046/hr; Vd = 12L (volume of the extracellular
space): What is the Css?
A. ?
4.9 ug/ml
B. ?
9.7 ug/ml
C. ?
16.2 ug/ml
D. ?
14.6 ug/ml
E. ?
20 ug/ml
3. Constant Infusion: the infusion rate for Drug X is
300 ug/min; half-life for elimination is 15 hours; ke
= 0.046/hr; Vd = 40L: What is the Css?
A. ?
4.9 ug/ml
B. ?
9.7 ug/ml
C. ?
16.2 ug/ml
D. ?
14.6 ug/ml
E. ?
none of the above
4. Constant Infusion: the infusion rate for Drug X is
450 ug/min; half-life for elimination is 15 hours; ke
= 0.046/hr; Vd = 40L: What is the Css?
A. ?
4.9 ug/ml
B. ?
9.7 ug/ml
C. ?
16.2 ug/ml
D. ?
14.6 ug/ml
E. ?
19 ug/ml
5. Constant Infusion: the infusion rate for Drug X is
300 ug/min; half-life for elimination is 15 hours; ke
= 0.046/hr; Vd = 40L: How long does it take to
reach 50% of Css?
A. ?
3 hours
B. ?
9 hours
C. ?
15 hours
D. ?
24 hours
E. ?
60 hours
6. Constant Infusion: what would be the infusion rate
for Drug X to attain a steady-state concentration of
25 ug/ml?; half-life for elimination is 15 hours; ke =
0.046/hr; Vd = 40L
A. ?
25 ug/min
B. ?
300 ug/min
C. ?
600 ug/min
D. ?
760 ug/ml
E. ?
0.019 ug/ml
7. Constant Infusion: the infusion rate for Drug X is
300 ug/min; half-life for elimination is 15 hours; ke
= 0.046/hr; Vd = 40L: How long does it take to
reach 90% of Css?
A. ?
7.5 hours
B. ?
15 hours
C. ?
30 hours
D. ?
50 hours
E. ?
60 hours
…

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